Sirtuin - Wikipedia
The first sirtuin was identified in yeast (a fungus) and named sir2. In more complex mammals, there are seven known enzymes that act in cellular regulation, as sir2 does in yeast.
什么是Sirtuins？跟NAD、NMN有什么关系？ - 知乎
Nov 16, 2023 · NMN是NAD+的直接前体，当NMN进入细胞后，它会被转化为NAD+，进而参与Sirtuin的表达调控。 NMN通过增加NAD+水平，可以间接影响Sirtuins蛋白的活性。 因为Sirtuins蛋白的活性 …
The sirtuin family in health and disease
Dec 29, 2022 · The sirtuin (SIRT) protein family, which are conserved proteins belonging to class III histone deacetylases, comprises seven members.1Notably, SIRTs share a nicotine adenine …
Circ Res 中国医学科学院陈厚早团队系统综述：Sirtuins在心血管疾病中 …
Mar 4, 2025 · 该综述及时且全面地总结了在心血管疾病领域中Sirtuin蛋白家族的研究状态，并指出Sirtuin研究领域在未来所面临的挑战，承前启后，为下一阶段Sirtuin相关研究拉开了序幕。
Sirtuin - an overview | ScienceDirect Topics
Sirtuins are master regulators of a wide range of metabolic processes in mammalian cells, and aging affects sirtuin-associated molecular pathways. Sirtuins could be on both sides of redox regulation, …
The sirtuin family in health and disease - PubMed
Dec 29, 2022 · Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous …
What Are Sirtuins and How Do They Work? - Biology Insights
Each sirtuin has a specific cellular location, allowing it to regulate different compartments and processes. For instance, SIRT1, SIRT6, and SIRT7 are predominantly found in the nucleus, where they interact …
The role of sirtuins in cellular homeostasis - PMC
A modification of the sirtuin activity by small molecule activators or suppressors may provide new opportunities for the treatment of type II diabetes, obesity, and neurodegenerative diseases …
SIRT2在肝癌发生发展中的作用 - University of Winchester
R735.7; 沉默信息调节因子 (silence information regulator,sirtuin)是一类高度保守的烟酰胺腺嘌呤二核苷酸 (NAD+)依赖的组蛋白去乙酰化酶,在衰老、代谢、细胞凋亡、基因转录、炎症发生等过程中发挥重要 …
Sirtuins as regulators of metabolism and healthspan - Nature
Mar 7, 2012 · Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing.