SAN DIEGO — The Giants flew into San Diego with the second-best record in baseball. They return to San Francisco with the third-best record in the division, suffering a two-game sweep at the hands of the Padres after losing, 5-3, on Wednesday at Petco Park.

The San Diego Padres are set to take on the San Francisco Giants in the first contest of a two-game series on Tuesday. Just in the nick of time, San Diego is receiving two key players back in the lineup for this clash.

San Francisco Giants outfielder Mike Yastrzemski hits a homer in the eighth inning against the San Diego Padres on Wednesday at Petco Park.Yaz's fifth homer of 2025 season cuts Giants' deficit vs. Pad

Xander Bogaerts went 2 for 4 with three RBIs, Nick Pivetta struck out nine in 5 1/3 innings and the San Diego Padres beat the San Francisco Giants 7-4 on Tuesday night. It was San Diego’s most runs since scoring 10 against the Chicago Cubs on April 14.

Bogaerts' seventh-inning, two-run homer helped the Padres to a 7-4 win over the Giants and ended an unwanted individual streak.

Elias Díaz homered and scored twice, and Fernando Tatis Jr. had three hits for the San Diego Padres, who beat the San Francisco Giants 5-3 for a two-game sweep.

San Diego Padre starting pitcher Michael King was masterful on the mound during Wednesday game against the Giants at Petco Park. King pitched 5.2 innings, gave up 3 hits hits, had 6 strikeouts and allowed 1 run,

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The San Francisco Giants (19-11) and the San Diego Padres (18-11) wrap up a 2-game series Wednesday. First pitch from Petco Park is at 4:10 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Get San Francisco vs San Diego baseball betting preview, spread and over/under insights for their matchup on April 30.