The San Francisco 49ers offense has been a hotbed for fantasy ... setting up more opportunities for his breather back. Is ...

Linebacker Dre Greenlaw is the consensus most important free agent to re-sign this offseason, a topic one 49ers insider ...

The San Francisco 49ers have a handful of difficult decisions to make when it comes to their collection of free agents in the ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

The 49ers lost another running back Sunday. Isaac Guerendo was carted off the field with injuries to his left knee and ankle. The team ruled out his ...

The San Francisco 49ers' running ... After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac ...

Yet another San Francisco 49ers running ... Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs.

The ongoing epidemic in the San Fransisco 49ers' backfield ... Jordan Mason, and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for ...

The San Francisco 49ers just can’t catch a break ... At the running back position alone, they've lost McCaffrey, Jordan Mason and Elijah Mitchell for the season, and now it looks like Isaac ...

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...