The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...

Star running back Christian McCaffrey has remained healthy during his 49ers career to this point ... for his breather back.

(Photo by Norm Hall/Getty Images) Patrick Taylor Jr., the 49ers’ fifth-string running back to start the season ... and Jordan Mason (ankle), as well as Eli Mitchell’s preseason hamstring ...

(Photo by Norm Hall/Getty Images) Patrick Taylor Jr., the 49ers’ fifth-string running back to start the season ... and Jordan Mason (ankle), as well as Eli Mitchell’s preseason hamstring ...

The San Francisco 49ers' running back corps is expected to lose a fourth ... with a high ankle sprain he suffered on Dec. 1. Elijah Mitchell has also missed the entire 2024 season with a hamstring ...

Guerendo will join Christian McCaffrey and Jordan Mason as injured 49ers running backs. Another running back, Elijah Mitchell, has missed the entire season, meaning Taylor is likely viewed as the ...

49ers running back Isaac Guerendo San Fransisco is officially ... "After losing RBs Christian McCaffrey, Jordan Mason, and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers ...

Taylor is next man up in the running back room, with rookie Isaac Guerendo ruled out Friday before the 49ers embarked on ... Jerick McKinnon, Elijah Mitchell, Trey Sermon, Deebo Samuel, McCaffrey ...