Intellia: Moving To 'Hold' Rating In Light Of Nex-Z Uncertainty In ATTR Patients (Downgrade)

Intellia Therapeutics, Inc. is rated Hold due to uncertainty from dosing pause in its MAGNITUDE program for ATTR. Learn more ...

Computationally accelerated organic synthesis: Optimal ligand prediction for generating reactive alkyl ketone radicals

Because ketones are widespread in organic molecules, chemists are eager to develop new reactions that use them to form ...

Unique enzymes use never-before-seen mechanism to resist antibiotics

Life just got more difficult for those fighting antibiotic-resistant superbugs. Researchers at McGill University have ...
EMBO Press

Mechanism of autophagy initiation by transmembrane selective autophagy receptors

Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby ...

Earth’s first life may have been sparked by underwater thermal vents

Before sunlight ever reached the planet, another force may have sparked life—electricity. Deep beneath the ocean floor, ...
Labmate Online

Tokyo team unveils novel NMR method to reveal enzyme movements in unprecedented detail

Researchers in Japan have developed a Nuclear Magnetic Resonance spectroscopy technique that captures how enzymes move and ...

Terns Pharmaceuticals: GLP-1 Obesity Drug Cut Warrants Downgrade To 'Hold' Rating

Terns Pharmaceuticals halts its TERN-601 obesity program due to insufficient efficacy and safety concerns. Click here to read ...
C&EN

Combining Reactive Quantum-Mechanical Molecular-Dynamics Simulations with Mutagenesis, Crystallography, and Enzyme Kinetics to Reveal Plausible Steps of Isocyanide Hydratase ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. A complete ...
Edhat

New Catalysis Method Can Generate a Library of Novel Molecules for Drug Discovery

Using reprogrammed biocatalysts, researchers are pushing the boundaries of enzymatic synthesis with a method that opens the door to a diverse array of valuable compounds. Reporting in the journal ...
EurekAlert!

Deciphering the physical binding mechanism of enzyme–photosensitizer facilitates catalysis-augmented photodynamic therapy

Photodynamic therapy (PDT), characterized by its non-invasive nature and precise spatiotemporal selectivity, has garnered considerable attention for its applications in tumor and anti-infection ...