Photodynamic therapy (PDT), characterized by its non-invasive nature and precise spatiotemporal selectivity, has garnered considerable attention for its applications in tumor and anti-infection ...
Enzyme mechanisms are often probed by structure-informed point mutations and measurement of their effects on enzymatic properties to test mechanistic hypotheses. In many cases, the challenge is to ...
image: Synthesizing hybrid enzyme catalysts in situ to improve and expand enzymatic catalysis is an important way to address challenges of industrial biocatalysis. In this account, the construction ...
γ-Glutamylcysteine synthetase (γGCS), a rate-limiting enzyme in glutathione biosynthesis, plays a central role in glutathione homeostasis and is a target for development of potential therapeutic ...
Life just got more difficult for those fighting antibiotic-resistant superbugs. Researchers at McGill University have ...
Pyruvate formate-lyase (PFL) from Escherichia coli uses a radical mechanism to reversibly cleave the C1-C2 bond of pyruvate using the Gly 734 radical and two cysteine residues (Cys 418, Cys 419). We ...
This is a preview. Log in through your library . Abstract We have used chemical protein synthesis and advanced physical methods to probe dynamics-function correlations for the HIV-1 protease, an ...
Scientists have developed a method with which an enzyme at work can be 'photographed'. Their method makes it possible to better understand the function of important biomolecules. The researchers also ...
(b. 1964) B.S., 1986, University of Massachusetts, Amherst; Ph.D., 1991, Brown University; National Institutes of Health Postdoctoral Fellow, 1991 – 1994 ...
BUFFALO, N.Y. -- Bioorganic reactions, essentially the reactions that distinguish living systems from nonliving ones, will be the subject of an international symposium to be held at the University at ...
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