G protein-coupled receptors (GPCRs) are among the most abundant proteins in the body, and responsible for triggering numerous and diverse signaling cascades. Signaling through the MAPK/ERK pathway is ...

With this knowledge, scientists are seeking to better understand the role of GPCRs in islet biology and hormone secretion, and how signaling in the cell through these receptors is disrupted in ...

Over the years, chemical biology methods have made an important contribution to the study of integral membrane proteins. A ...

"GPCRs are important drug targets mainly due to their involvement in signaling pathways related to many diseases," she explained, citing mental and endocrinological disorders, viral infections ...

Over the years, chemical biology methods have made an important contribution to the study of integral membrane proteins. A ...

As the largest family of cell surface receptors, GPCRs account for over one-third of drug screening efforts. Inositol-1-phosphate (IP1) is a metabolite of Gq signaling and has been shown to be very ...

But it does offer a new path forward for improving understanding of neuronal signaling and the role of GPCRs as drug targets. "Ideally, we aim to be able to create a brain map for multiple ...

We also develop phototropin and cryptochrome-based optogenetic tools for regulating G protein signaling independent of GPCRs. These engineered tools allow the acquisition of dynamic molecular pictures ...

Septerna may be yet to disclose “any meaningful clinical data,” but the biotech clearly thinks there will be investor appetite for its G protein-coupled receptors (GPCRs). The South San ...