G protein-coupled receptors (GPCRs) are among the most abundant proteins in the body, and responsible for triggering numerous and diverse signaling cascades. Signaling through the MAPK/ERK pathway is ...

"GPCRs are important drug targets mainly due to their involvement in signaling pathways related to many diseases," she explained, citing mental and endocrinological disorders, viral infections ...

Classically, the GPCR signaling pathway is considered to be a three-component system that involves a seven-transmembrane-domain receptor, a trimeric G-protein complex (Gα, Gβ, Gγ) and an effector.

We also develop phototropin and cryptochrome-based optogenetic tools for regulating G protein signaling independent of GPCRs. These engineered tools allow the acquisition of dynamic molecular pictures ...

But it does offer a new path forward for improving understanding of neuronal signaling and the role of GPCRs as drug targets. "Ideally, we aim to be able to create a brain map for multiple ...

Septerna may be yet to disclose “any meaningful clinical data,” but the biotech clearly thinks there will be investor appetite for its G protein-coupled receptors (GPCRs). The South San ...

In particular, GPCRs play essential roles in the central nervous system, including neurotransmission and neuronal metabolism, as well as in energy homeostasis, including modulation of insulin ...

the GPCR target of the hormone relaxin. The relaxin portion of the molecule binds to the RXFP1 or relaxin family peptide receptor 1, activating intracellular signaling cascades that lead to ...