Proton pump inhibitors are a class of medications used to treat conditions like GERD and ulcers. They work by blocking the ...

Taking Out OGA. The rationale behind small-molecule OGA inhibition is that these drugs will decrease tau hyperphosphorylation ...

Rutgers Health research has uncovered why a relatively new antibiotic for tuberculosis (TB) works against multidrug-resistant strains, potentially inspiring improved treatments and drug development ...

Most of the disease-causing bacteria secrete matrix-like layers around themselves called biofilms. These biofilms act as ...

Researchers reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected 'second jobs' within the nucleus, orchestrating critical ...

Metabolic enzymes, typically associated with energy production, are now discovered to also play essential roles in the nucleus, such as orchestrating cell division and DNA repair. This breakthrough, ...

Metabolic enzymes are moonlighting outside of their traditional neighbourhood ... The research on IMPDH2 also studied its interaction with PARP1, a protein already targeted by existing cancer drugs.