Researchers found that furanodienone (FDN), a compound in ginger, activates pregnane X receptor (PXR) to reduce gut ...

An international team led by researchers at the University of Toronto has found a compound in ginger, called furanodienone ...

An international team led by researchers at the University of Toronto has found a compound in ginger, called furanodienone (FDN), that selectively binds to and regulates a nuclear receptor involved in ...

Through a screen to identify chemical components of ginger that bind to receptors associated with IBD, the team observed a strong interaction between FDN and the pregnane X receptor (PXR).

In addition, alternative sinusoidal efflux transporters, organic solute transporter alpha/beta (OSTα/β) and MRP4 were upregulated, and pregnane X receptor (PXR, NR1I2) levels decreased.

A team of international researchers, led by scientists from the University of Toronto, has discovered a compound in ginger ...

Pregnane X receptor (PXR, NR1I2), a prototypical member of the nuclear receptor superfamily, has been implicated in various processes including metabolism, immune response, and inflammation. The ...