Injuries stacked up quickly for the San Francisco 49ers leading up to their Week 3 showdown with the Los Angeles Rams.

Brown and Odum allowed Justin Jefferson to get behind them for a 97-yard touchdown pass from Sam Darnold. Both are considered ...

The Niners will perhaps be without arguably their three most important offensive weapons, sidelined stars Christian McCaffrey ...

The Eagles defense has gotten run over through two weeks. Philadelphia has allowed an NFL-high 6.4 yards per carry and given up 157.5 rush yards per game. Can it flip the script in New Orleans?

The spread has moved one point in the Rams’ direction since Monday, likely because of the 49ers’ recent injury news ...

Taylor Britt said the Washington Commanders offense under Kliff Kingsbury doesn't ask rookie QB Jayden Daniels to do much.

With stud wide receiver (and quasi-backup running back) Deebo Samuel Sr. out in Week 3, San Francisco will continue to lean on Mason in a divisional matchup against the Rams. It's a smash opportunity ...

Everything you need to know about the Rams' home game against the NFC West rival San Francisco 49ers, including start time, ...

Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other ...

Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and ...

Currently, the 49ers sit at a 1-1 record following a disappointing loss to the Minnesota Vikings, amplifying the urgency for ...

The San Francisco 49ers are facing another blow to their offense after star tight end George Kittle missed Thursday's ...