On Wednesday, hours after Trey Parker and Matt Stone signed a $1.5 billion, 50-episode deal with Paramount, the 27th season premiere of “South Park” aired on Comedy Central.

Nearly three decades into its existence, the crass animated series just delivered one of its most topical and controversial episode of all times, even getting an angry response from President Trump's...

Clips from the premiere quickly spread through social media, with the show’s signature crude humor proving a hit—many were satisfied to see schoolyard taunts used against a president known for punchi...