Through its collaboration with Variational AI, Rakovina Therapeutics utilized the Enki™ generative AI platform to identify novel small-molecule candidates predicted to meet a defined target product ...

DNA damage repair (DDR) enzymes, including Ataxia telangiectasia and Rad3-related protein serine/threonine kinase (ATR), are crucial for maintaining stability in cells. Inhibition of DDR enzymes has ...

Thus, the phase 3 TOPAZ-1 trial (NCT03875235) made big news in 2021 when it met its primary overall survival (OS) end point in an interim analysis. Among patients with newly diagnosed advanced BTC, ...

Written by: Evan Yu, MD, Section Head of Cancer Medicine in the Clinical Research Division at Fred Hutchinson Cancer Center. He also serves as the Medical Director of Clinical Research Support at the ...

Aging is the continuous degradation of biological function and structure with time, and cellular senescence lies at its core. DNA damage response (DDR) can activate Ataxia telangiectasia-mutated ...

Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency (ADSLD) causes numerous neurodevelopmental pathologies, including ...

Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, 310 Milton Road, Milton, Cambridge CB4 0WG, U.K.

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

Sun-induced skin lesions, in particular actinic keratosis, are generally considered as premalignant skin lesions that can progress into squamous cell carcinoma (SCC) and invasive SCC if left untreated ...

1Cancer Research Institute, Seoul National University, Seoul, Korea. 2Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. Search for other works by this author on: 1Cancer ...