As an embryo develops from a small cluster of stem cells, those once "blank slate" cells begin to take on more specialized ...

Scientists from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and St. Jude Children's ...

What can pooled CRISPR screening and protein‑level readouts reveal that transcriptomics alone can't? Explore how single‑cell ...

Signaling is fundamental to how cells sense and respond to their environment—but in immune cells, those signals must be precisely amplified to mount an effective defense against invasive threats. New ...

The design of new calcium channels, built bottom-up from scratch, was reported last week in Nature. "Biochemists have been studying ion channels for decades and debating about how they work for almost ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

Blocking a tumor antioxidant restored T cell activity and made some resistant cancers more responsive to immunotherapy in mice.

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns. Scientists at St. Jude Children's ...