The 2025 NFL regular season kicks off its second month with an excellent Week 5 schedule full of matchups that promise to be entertaining.

How to watch NFL Week 5 schedule games Sunday, including Vikings-Browns, Texans-Ravens, Broncos-Eagles, Lions-Bengals, Patriots-Bills, Giants-Saints.

There are several marquee matchups on the Week 5 docket in the NFL, including a matchup between the Buffalo Bills and New England Patriots.

Rounding out the afternoon in the late window for Week 5 will be Tennessee at Arizona, Detroit in Cincinnati, taking on the Bengals, and Washington visiting the West Coast to face the Los Angeles Chargers. It's Week 5, and the NFL is down to its final two undefeated teams in the Eagles and Buffalo Bills.

The NFL Week 5 schedule will conclude with the Kansas City Chiefs visiting the Jacksonville Jaguars on 'Monday Night Football.' Kansas City (2-2) has rebounded from an 0-2 straight with back-to-back wins over the Giants and Ravens.

First, in defense of two games that didn’t make the cut. One of the best Week 5 matchups is the defending champion Eagles against the ascending Denver Broncos, but it features two elite defenses with extra-nasty pass rushes. Worth watching? Definitely. High-scoring? Maybe not.

The NFL Week 5 schedule is headlined on Monday with Chiefs at Jaguars. See the NFL schedule for Week 5 in Nashville here.

SportsLine's model is projecting 261.8 yards for Mahomes as he's in a spot where the Chiefs might rely heavily on their passing attack. The three-time NFL MVP threw for 270 yards in Week 4, and the model rates this as a strong 4.5-star play. See more NFL props here.