2025 Week 6 NFL picks, odds, best bets from proven model
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Check out our best bets as the curtain draws on Week 5 with an MNF matchup between the Chiefs and Jaguars on October 6, 2025.
Detroit enters the game boasting the league's top scoring offense, featuring productive talent up and down the lineup. That includes receivers Amon-Ra St. Brown and Jameson Williams, tight end Sam LaPorta and the dynamic running back tandem of Jahmyr Gibbs and David Montgomery.
Sam Farmer makes his picks and predictions for Week 6 of the NFL season, with the Lions defeating the Chiefs in prime time and the Seahawks improving to 4-2.
The Bengals and Ravens are both missing their quarterbacks, but so are the 49ers. It could get worse for Cincy and Baltimore this week.
The New York Giants will play host to the Philadelphia Eagles on Oct. 9 at MetLife Stadium. The Eagles (4-1) are coming off their first loss of the season to the Denver Broncos and hope to get back on track against the Giants (1-4) who lost 26-14 to New Orleans on Oct. 5.