The Arizona Cardinals defeated the New Orleans Saints 20-13 in a NFL Week 1 matchup on Sunday. Quarterback Kyler Murray threw for 163 yards and two touchdowns, and second-year running back Trey Benson had a career-best day with 69 yards on eight carries.

Sep 7, 2025; New Orleans, Louisiana, USA; New Orleans Saints tight end Juwan Johnson (83) grabs a pass in the end zone but Arizona Cardinals safety Jalen Thompson (34) knocks the ball loose in for an incomplete pass during the fourth quarter at Caesars Superdome. Mandatory Credit: Matthew Hinton-Imagn Images / Matthew Hinton-Imagn Images

Kyler Murray threw two touchdown passes and the Arizona Cardinals narrowly held on for a 20-13 victory over penalty-prone New Orleans on Sunday in the Saints’ first game under rookie coach Kellen Moore.

Kyler Murray threw two touchdown passes and the Arizona Cardinals stymied a New Orleans Saints comeback attempt to earn a 20-13 Week 1 victory Sunday at the Caesars Superdome. Trailing by 7, the Saints got the ball with under two minutes to play and drove to Arizona’s 18-yard line.

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Josh Naylor hit a go-ahead, two-run double in the sixth inning to help the Seattle Mariners beat the St. Louis Cardinals 4-2.

Other anticipated matchups to make Week 2 NFL bets on include Cowboys vs. Giants (+5.5) and a Super Bowl rematch in Chiefs vs. Eagles (-1). The motivation factor will be at an all-time high for Kansas City as one shouldn't underestimate that when making Week 2 NFL picks.