Rune 2: Class - Tangled Web: Joy: Any Purple (Joy, Beast, Jubilation) Arms - Tangled Web: Cunning: ... then JpDeathBlade’s rune combination sheet is the way to go.

Runes in Diablo 4 are used for creating Runewords and crafting Mythics, and these are the best ways to farm them.

The Rune of Invocation then is the effect of the Ritual's cause, as it were, offering a specific buff, such as 2.5% increased Critical Strike chance for five seconds.