The strategies biopharmaceutical manufacturers currently use to limit protein misfolding are complex, time-consuming, and generate low yields with only limited scalability. Covalent organic frameworks ...

A new study has described a potential mechanism that could help explain why some proteins refold in a different pattern than expected. The research showed that a type of misfolding, called ...

Inclusion bodies, once considered a hindrance in recombinant protein production, are now recognised for their potential as reservoirs of bioactive proteins and functional biomaterials. In bacterial ...

"Non-covalent lasso entanglement is a class of misfolding we recently identified where a loop of the protein traps another segment of the protein, essentially intertwining itself incorrectly," O'Brien ...