A team of scientists at Cold Spring Harbor Laboratory reports on Thursday their success in solving the molecular structure of a key portion of a cellular receptor implicated in Alzheimer's, ...
With the ink barely dry on a partnership deal with Allergan, Aptinyx has announced plans for an $80 million IPO to accelerate work on its drugs for neurological disorders. The Evanston, Illinois-based ...
The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is ...
Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...
CT scan of a brain of a patient with subdural hemorrhage, interhemispheric hemorrhage and cerebral edema from trauamatic brain injury (TBI). (CT scan of a brain of a patient with subdural hemorrhage, ...
Structural biologists have obtained a precise molecular map of the binding site for an allosteric inhibitor in a subtype of the NMDA (N-methyl-D-aspartate) receptor, which is commonly expressed in ...
Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression. NMDA receptors, critical for learning and memory, are ...
Just a few months after heralding some strong data for their lead depression drug, Naurex has wrapped a Phase II study of its number two NMDA treatment after getting the positive efficacy data it was ...
Cold Spring Harbor, NY - Structural biologists at Cold Spring Harbor Laboratory (CSHL) and Janelia Research Campus/HHMI, have obtained snapshots of the activation of an important type of brain-cell ...
In acutely dissociated rat hippocampal CA1 neurons, YY-23 selectively and reversibly inhibited NMDA-induced currents with an EC 50 value of 2.8 μmol/L. This inhibition of NMDA-induced currents by ...
Male Wistar rats (n=100; Charles River Laboratories, Raleigh, NC) weighing 300–320 (behavioral experiments) or 200–300 g (electrophysiological experiments) were housed in groups of 2–3 per cage in an ...
Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression. NMDA receptors, critical for learning and memory, are ...
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