NFL regular season officially kicks off on Thursday, November 20, with a primetime AFC showdown between the Buffalo Bills and Houston Texans at NRG Stadium on Prime Video. Houston will be without star quarterback CJ Stroud for a third straight game as he remains in concussion protocol,

The NFL schedule in Week 12 should provide some fireworks. The outings include the Tampa Bay Buccaneers playing the Los Angeles Rams at SoFi Stadium. Read through our betting breakdown for the NFL's Week 12.

The Tennessee Titans host the Seattle Seahawks on Nov. 23. Here are The Tennessean's scouting report and score prediction.

For the Lions, this game is part of a tough post-bye week schedule, wherein they play the Vikings (loss), Commanders (win), Eagles, Giants, Packers, Cowboys and Rams all in a row. That game against Dallas the week after Thanksgiving is also on "Thursday Night Football."

The Colts have emerged as one of the top teams in the NFL through 11 weeks, but they will be challenged as they face the most difficult schedule among AFC teams over the final seven weeks. Every opponent remaining is .500 or better. So far this season, the Colts are 2-2 in games against teams that are currently .500 or better.

According to NOLA.com's Jeff Duncan, team president Dennis Lauscha revealed that the Saints are targeting a game in Paris as early as the 2026 campaign. The NFL and stadium officials in Paris are reportedly "working" to finalize a deal and there likely will be an official announcement over the next several weeks.