Maintaining a normal physiologic acid-base balance is essential for the functioning of every organ system in the body. The renal and pulmonary systems are the primary regulators of acid-base balance.

Author: The SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials GroupAuthor Info & Affiliations In this pragmatic, adaptive, double-blind, randomized trial ...

Acute severe asthma can precipitate lactic acidosis through multiple pathways. Severe bronchoconstriction and hypoxaemia increase work of breathing and shift metabolism towards anaerobic glycolysis, ...

Sodium bicarbonate is an antacid medication that can help treat people with kidney disease who develop metabolic acidosis. Kidney disease, also known as “chronic kidney disease” (CKD), is a condition ...

A Japanese registry has identified a blind spot in the routine care of patients with chronic kidney disease (CKD). Serum bicarbonate levels are rarely measured, leaving metabolic acidosis largely ...