Gardner’s team first focused their efforts on the challenging task of creating mouse strains that could recapitulate the complex transformation in a simplified model. “It took three years to make ...

Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for ...

In recognition of Breast Cancer Awareness Month, join us for a live webinar to uncover the complexity of tumor biology and the surprising resilience of normal tissue. This event will feature two ...

In short, oncogenic forms of BRAF adopt a structure that is almost identical to the naturally active form of the protein. Altered forms of BRAF can thus escape the auto-inhibition mechanism and, in a ...

Kinases play important roles in diverse cellular processes, including signaling, differentiation, proliferation, and metabolism. They are frequently mutated in cancer and are the targets of a large ...

Antiretroviral therapy has decreased the risk of lymphoma in the HIV-positive patient population, yet the incidence is still approximately 70-times greater than the incidence in the noninfected ...

Ovarian cancer (OC), one of the three most common gynecological malignancies, is characterized by low early detection rates and poor prognosis. Patients with OC face a high risk of developing ...