Biologists are closing in on a puzzle that seems to turn classic evolutionary logic inside out, yet may be so common that it ...

For a long time, evolutionary biologists have thought that the genetic mutations that drive the evolution of genes and proteins are largely neutral: they're neither good nor bad, but just ordinary ...

The study of experimental evolution in Escherichia coli has provided unprecedented insights into the mechanisms of adaptive mutations, elucidating how populations diverge and optimise their fitness ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

A study published in the Proceedings of the National Academy of Sciences by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not ...

Missense variants remain a challenge in genetic interpretation due to their subtle and context-dependent effects. While current prediction models perform well in known disease genes, generalizability ...

Researchers published a new study, “Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution,” in Cell that they say solves the mystery of what drives the genomic ...

A recently published study in Nature Communications, led by a group from the Bellvitge Biomedical Research Institute (IDIBELL) with the participation of the Germans Trias i Pujol Research Institute ...

In 1943, a physicist and a biologist published a paper that confirmed one of the central pillars of Darwin's theory of evolution. The paper, by Max Delbrück of Vanderbilt University and Salvador Luria ...

A groundbreaking study published in this week’s issue of PNAS by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not randomly but more ...