The San Francisco 49ers could make a major move ahead of their matchup with Seattle to determine the No. 1 seed.

Saturday night celebrates the Faithful as the 49ers host the Seattle Seahawks in primetime for the final regular-season game. The NFC West crown and the No. 1 seed are on the line.

NFL Week 18 odds, picks, predictions, TV channel, streaming information for Saturday football game between Seattle Seahawks and San Francisco 49ers.

The San Francisco 49ers defense didn't get many stops against the Chicago Bears on Sunday. But the one that mattered the most may have been helped by two defenders improvising beyond Robert Saleh's play call.

Seattle presents many challenges, but one of the most difficult matchups is with wide receiver Jaxon Smith-Njigba, who isn’t a household name yet in his third year out of Ohio State but probably should be. The Seahawks felt good enough about him to trade D.K. Metcalf, their No. 1 receiver, to Pittsburgh in the offseason.

Watch the NFL's official Week 18 game preview for Seattle Seahawks vs. San Francisco 49ers. Go on the field with the San Francisco 49ers players during the team's 42-38 victory over the Chicago Bears. Watch the NFL's official Week 18 game preview for Seattle Seahawks vs. San Francisco 49ers.

After Brock Purdy put up another five-touchdown performance to lead the San Francisco 49ers to a massive win Sunday, even the quarterback’s biggest critics and haters can’t help but marvel at his torrid run.

The San Francisco 49ers will be wearing all black Saturday, Jan. 3, to face off against the Seattle Seahawks. But it’s not in mourning for the end of the regular season. Players will be decked out in their “rivalries” uniforms for the final game of the regular season, the 49ers announced.

Seattle Seahawks' general manager John Schneider gets an A+ for a 2025 draft class led by Grey Zabel and Nick Emmanwori.