The sides have faced each other five times in the last six Champions League seasons, and have been host to many classic ties over the last decade, becoming a modern-day European rivalry.
Guillem Balague examines the problems that have led Manchester City and Real Madrid to meet in the Champions League play-off.
The champions of England ... into European football's modern classic. Manuel Pellegrini's Manchester City were hoping to reach their first Champions League final but a deflected Gareth Bale ...