Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results, researchers are now watching individual molecules collide with cell ...

In two new studies, scientists at Oregon Health & Science University have uncovered detailed blueprints of how certain molecular "gates" in human cells work—findings that could open doors to new ...

A single receptor in blood vessels can trigger either harmful inflammation or protective healing, but scientists have struggled to understand how this is possible. UC San Diego researchers revealed ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

T cell lymphomas are notoriously difficult to treat because immunotherapy, despite being one of the most effective therapies for treating cancer, can't easily distinguish cancerous T cells from ...

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

Details and references regarding individual diseases are provided in the Supplementary Appendix. CIDP denotes chronic inflammatory demyelinating polyneuropathy, Covid-19 coronavirus disease 2019, and ...

Wistar Institute scientists have designed a two-vaccine approach that not only targets the tumors’ unique molecular identity ...

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...