Heart failure with preserved ejection function is a lethal form of heart failure, with few effective treatments. A team from Nagoya University Graduate School of Medicine have identified an enzyme, ...

Researchers discovered that ALPK2, a heart-specific enzyme, may protect against HFpEF by activating TPM1 in heart muscle ...

Currently, there are only two drugs for HFpEF: SGLT2 inhibitor and ARNI. The ALPK2/TPM1 regulatory axis may provide a unique therapeutic target for HFpEF, allowing the development of new treatment ...