REST Gene - GeneCards | REST Protein | REST Antibody
WEBAug 6, 2024 · REST (RE1 Silencing Transcription Factor) is a Protein Coding gene. Diseases associated with REST include Fibromatosis, Gingival, 5 and Deafness, Autosomal Dominant 27. Among its related pathways are PIP3 activates AKT signaling and Gene expression (Transcription).
RE1-silencing transcription factor - Wikipedia
WEBRE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor. [5] [6] [7] REST is expressly involved in the repression of neural genes in non-neuronal cells.
REST, a master transcriptional regulator in neurodegenerative …
WEBREST (also called NRSF) is a gene silencing transcription factor that is widely expressed during embryogenesis and plays a strategic role in end-stage neuronal differentiation [1, 2].
Comprehensive analysis of the REST transcription factor regulatory ...
WEBMay 6, 2024 · The RE1-silencing transcription factor (REST) acts either as a repressor or activator of transcription depending on the genomic and cellular context. REST is a key player in brain cell differentiation by inducing chromatin modifications, including DNA methylation, in a proximity of its binding sites.
REST , a master regulator of neurogenesis, evolved under …
WEBAug 25, 2017 · The transcriptional repressor REST regulates many neuronal genes by binding RE1 motifs. About one third of human RE1s are recently evolved and specific to primates. As changes in the activity...
REST and stress resistance in ageing and Alzheimer’s disease
WEBMar 19, 2014 · Here we show that induction of the repressor element 1-silencing transcription factor (REST; also known as neuron-restrictive silencer factor, NRSF) is a universal feature of normal ageing in...
REST, a master transcriptional regulator in ... - ScienceDirect
WEBFeb 1, 2018 · The gene silencing transcription factor REST not only silences, but also activates gene transcription. Whereas REST orchestrates fine-tuning of plasticity genes during development, it represses stress genes in aging neurons.
Systematic analysis identifies REST as an oncogenic and ... - Nature
WEBFeb 21, 2023 · The repressor element 1 silencing transcription factor (REST) has been proposed to function as a transcription factor to silence gene transcription by binding to repressor element 1...
REST and the RESTless - PMC - National Center for Biotechnology …
WEBOverview of REST function in self-renewal of embryonic stem cells and neurogenesis in neural and non-neural cells. In embryonic stem cells, REST represses the expression of miR-21, a negative regulator of proteins involved in self …
REST RE1 silencing transcription factor - NIH Genetic Testing …
WEBMar 5, 2024 · This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor.