Genetic diversity and molecular evolution of human respiratory ...
WEBJun 21, 2021 · Human respiratory syncytial viruses (RSVs) are classified into two major groups (A and B) based on antigenic differences in the G glycoprotein. To investigate circulating characteristics and...
Molecular mechanism of respiratory syncytial virus fusion ... - PubMed
WEBHere we show that these inhibitors bind to a three-fold-symmetric pocket within the central cavity of the metastable prefusion conformation of RSV F. Inhibitor binding stabilizes this conformation by tethering two regions that must undergo a structural rearrangement to facilitate membrane fusion.
Respiratory syncytial virus: from pathogenesis to potential …
WEBSep 27, 2021 · First-in-Human Randomized Study to Assess the Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus (RSV) Vaccine Based on Chimpanzee-Adenovirus-155 Viral Vector-Expressing RSV Fusion, Nucleocapsid, and Antitermination Viral Proteins in Healthy Adults.
A new mechanism of respiratory syncytial virus entry inhibition …
WEBIMPORTANCE . Respiratory syncytial virus (RSV) infection is a major public health concern, and many small-molecule candidates targeting the viral fusion (F) protein are associated with a considerable risk of inducing drug-resistant mutations.
Respiratory syncytial virus infection and novel interventions
WEBJul 12, 2023 · Crystal structures of the respiratory syncytial virus fusion (F) protein in the pre-fusion (pre-F; lower left) and post-fusion state (post-F; lower right) are shown.
Therapeutic efficacy of a respiratory syncytial virus fusion ... - Nature
WEBAug 1, 2017 · Here we report the structure of JNJ-53718678 bound to respiratory syncytial virus fusion (F) protein in its prefusion conformation, and we show that the potent nanomolar activity of...
Structure of Respiratory Syncytial Virus Fusion Glycoprotein in …
WEBRespiratory syncytial virus (RSV) invades host cells via a type I fusion (F) glycoprotein that undergoes dramatic structural rearrangements during the fusion process. Neutralizing monoclonal antibodies, such as 101F, palivizumab, and motavizumab, target two major antigenic sites on the RSV F glycoprotein.
Structure and Function of RSV Surface Glycoproteins - PMC
WEBOct 14, 2016 · Refolding the F protein to initiate fusion. In the prefusion form of the F 1 protein the fusion peptide (FP) at the N terminus of F 1 (turquoise) is followed by 4 short α-helices (blue) connected by 3 non-helical peptides.
Respiratory syncytial virus infections in adults: a narrative review
WEBRespiratory syncytial virus (RSV) is an enveloped RNA virus that causes respiratory infections in all age groups, in a predictable, seasonal pattern in temperate climates, with incidence that is relatively constant from year to year. ... and the fusion (F) protein, which enables the virus membrane to fuse with the target cell membrane.
Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older …
WEBFeb 15, 2023 · The primary objective was to show vaccine efficacy of one dose of the RSVPreF3 OA vaccine against RSV-related lower respiratory tract disease, confirmed by reverse-transcriptase polymerase chain...
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